Article
Pharmacogenetics of drug-metabolizing enzymes in Italian populations.
Drug metabolism and personalized therapy - 1 Jun 2015
Serpe Loredana, Canaparo Roberto, Scordo Maria Gabriella, Spina Edoardo
Abstract excerpt
Drug-metabolizing enzymes play a major role in the biotransformation and subsequent elimination of most drugs and xenobiotics from the body. Both phase I and phase II enzymes are highly polymorphic. Inter-individual differences in genes coding for drug-metabolizing enzymes are important for understanding variability in drug response and for individualization of drug prescription. The prevalence of genetic...
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