Article
A locked nucleic acid clamp-mediated PCR assay for detection of a p53 codon 249 hotspot mutation in urine.
The Journal of molecular diagnostics : JMD - 1 Sept 2011
Lin Selena Y, Dhillon Veerpal, Jain Surbhi, Chang Ting-Tsung, Hu Chi-Tan, Lin Yih-Jyh, Chen Shun-Hua, Chang Kung-Chao, Song Wei, Yu Lixin, Block Timothy M, Su Ying-Hsiu
Abstract excerpt
Hepatocellular carcinoma (HCC) has a 5-year survival rate of <10% because it is difficult to diagnose early. Mutations in the TP53 gene are associated with approximately 50% of human cancers. A hotspot mutation, a G:C to T:A transversion at codon 249 (249T), may be a potential DNA marker for HCC screening because of its exclusive presence in HCC and its detection in the circulation of some patients with HCC. A...
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