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Article

Vaccination-induced changes in human B-cell repertoire and pneumococcal IgM and IgA antibody at different ages.

Aging cell - 1 Dec 2011

Ademokun Alexander, Wu Yu-Chang, Martin Victoria, Mitra Rajive, Sack Ulrich, Baxendale Helen, Kipling David, Dunn-Walters Deborah K

Abstract excerpt

It is well known that older people are more susceptible to morbidity and mortality from infectious diseases, particularly from pulmonary diseases such as pneumococcal pneumonia where vaccines do not provide efficient protection as in younger populations. We have previously shown that the B-cell repertoire in the old is reduced and hypothesise that this may contribute to the impaired humoral responses of the...

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Identifiers

PMID: 21726404
DOI: 10.1111/j.1474-9726.2011.00732.x
PMCID: PMC3264704

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IGH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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