Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels.

Journal of neuroscience methods - 30 Aug 2011

Zhang Di, Thimmapaya Rama, Zhang Xu-Feng, Anderson David J, Baranowski John L, Scanio Marc, Perez-Medrano Arturo, Peddi Sridhar, Wang Zhi, Patel Jyoti R, DeGoey David A, Gopalakrishnan Murali, Honore Prisca, Yao Betty B, Surowy Carol S

Abstract excerpt

KCNQ2/3 voltage-gated potassium channels conduct low-threshold, slowly activating and non-inactivating currents to repolarize the neuronal resting membrane potential. The channels negatively regulate neuronal excitability and KCNQ2/3 openers are efficacious in hyperexcited states such as epilepsy and pain. We developed and utilized thallium influx assays to profile novel KCNQ2/3 channel openers with respect to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbamates
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to KCNQ Potassium Channels

Share to KCNQ2 Potassium Channel

Share to KCNQ3 Potassium Channel

Share to Mutation

Share to Phenylenediamines

Source

Identifiers

PMID: 21723881
DOI: 10.1016/j.jneumeth.2011.06.014

Genes

KCNQ2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels.PMID 21723881Read ↗

The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site.Semantic proximity Read ↗

Sequence determinants of subtype-specific actions of KCNQ channel openers.Semantic proximity Read ↗

Molecular determinants of KCNQ1 channel block by a benzodiazepine.Semantic proximity Read ↗

High-throughput Evaluation of Epilepsy-associated <i>KCNQ2</i> Variants Reveals Functional and Pharmacological HeterogeneitySemantic proximity Read ↗

Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.Semantic proximity Read ↗

Large-Scale Structure-Based Virtual Screening Identifies Diverse K <sub>Na</sub> 1.1 (KCNT1) Potassium Channel InhibitorsSemantic proximity Read ↗

Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels.Semantic proximity Read ↗

Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels.Semantic proximity Read ↗

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3Semantic proximity Read ↗

Development of phenotypic assays for identifying novel blockers of L-type calcium channels in neurons.Semantic proximity Read ↗

High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants.Semantic proximity Read ↗

High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 VariantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.