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Article

The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site.

Neuroscience letters - 13 Nov 2009

Padilla Karen, Wickenden Alan D, Gerlach Aaron C, McCormack Ken

Abstract excerpt

The mammalian KCNQ (Kv7) gene family is composed of five members (KCNQ1-5). KCNQ2, Q4 and Q5 (KCNQ2-5) channels co-express with KCNQ3 to form heterotetrameric voltage-gated K(+) (KCNQ2-5/3) channels that underlie the endogenous M-current and regulate neuronal excitability in CNS and PNS neurons. Openers of one or a mixture of these channels may be an attractive therapeutic agent for epilepsy and pain....

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Source

Identifiers

PMID: 19733209
DOI: 10.1016/j.neulet.2009.08.071

Genes

KCNQ2
KCNQ3
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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