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Article

Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Jun 2015

Kalappa Bopanna I, Soh Heun, Duignan Kevin M, Furuya Takeru, Edwards Scott, Tzingounis Anastasios V, Tzounopoulos Thanos

Abstract excerpt

Voltage-gated Kv7 (KCNQ) channels are voltage-dependent potassium channels that are activated at resting membrane potentials and therefore provide a powerful brake on neuronal excitability. Genetic or experience-dependent reduction of KCNQ2/3 channel activity is linked with disorders that are characterized by neuronal hyperexcitability, such as epilepsy and tinnitus. Retigabine, a small molecule that activates...

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Source

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Identifiers

PMID: 26063916
DOI: 10.1523/JNEUROSCI.5176-14.2015
PMCID: PMC4461688

Genes

KCNQ2
KCNQ4
KCNQ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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