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Article

Sequence determinants of subtype-specific actions of KCNQ channel openers.

The Journal of physiology - 1 Feb 2017

Wang Alice W, Yang Runying, Kurata Harley T

Abstract excerpt

KEY POINTS: Retigabine is a KCNQ voltage-gated potassium channel opener that was recently approved as an add-on therapeutic for patients with drug-resistant epilepsy. Retigabine exhibits very little specificity between most KCNQ channel subtypes, and there is interest in generating more potent and specific KCNQ channel openers. The present study describes the marked specificity of ICA069673 for KCNQ2 vs. KCNQ3,...

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Source

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Identifiers

PMID: 27506413
DOI: 10.1113/JP272762
PMCID: PMC5285613

Genes

KCNQ2
KCNQ3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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