Article
Network-based group variable selection for detecting expression quantitative trait loci (eQTL).
BMC bioinformatics - 30 Jun 2011
Wang Weichen, Zhang Xuegong
Abstract excerpt
BACKGROUND: Analysis of expression quantitative trait loci (eQTL) aims to identify the genetic loci associated with the expression level of genes. Penalized regression with a proper penalty is suitable for the high-dimensional biological data. Its performance should be enhanced when we incorporate biological knowledge of gene expression network and linkage disequilibrium (LD) structure between loci in high-noise...
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