Article
Network-guided sparse regression modeling for detection of gene-by-gene interactions.
Bioinformatics (Oxford, England) - 15 May 2013
Lu Chen, Latourelle Jeanne, O'Connor George T, Dupuis Josée, Kolaczyk Eric D
Abstract excerpt
MOTIVATION: Genetic variants identified by genome-wide association studies to date explain only a small fraction of total heritability. Gene-by-gene interaction is one important potential source of unexplained total heritability. We propose a novel approach to detect such interactions that uses penalized regression and sparse estimation principles, and incorporates outside biological knowledge through a...
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