Article
A genetical genomics approach to genome scans increases power for QTL mapping.
Genetics - 1 Mar 2011
Sun Guoying, Schliekelman Paul
Abstract excerpt
We describe a method for integrating gene expression information into genome scans and show that this can substantially increase the statistical power of QTL mapping. The method has three stages. First, standard clustering methods identify small (size 5-20) groups of genes with similar expression patterns. Second, each gene group is tested for a causative genetic locus shared with the clinical trait of interest....
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