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Article

Evolutionary pathways to NS5A inhibitor resistance in genotype 1 hepatitis C virus.

Antiviral research - 1 Oct 2018

Zhou Shuntai, Williford Sara E, McGivern David R, Burch Christina L, Hu Fengyu, Benzine Tiffany, Ingravallo Paul, Asante-Appiah Ernest, Howe Anita Y M, Swanstrom Ronald, Lemon Stanley M

Abstract excerpt

Direct-acting antivirals (DAAs) targeting NS5A are broadly effective against hepatitis C virus (HCV) infections, but sustained virological response rates are generally lower in patients infected with genotype (gt)-1a than gt-1b viruses. The explanation for this remains uncertain. Here, we adopted a highly accurate, ultra-deep primer ID sequencing approach to intensively study serial changes in the NS5A-coding...

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Identifiers

PMID: 30081054
DOI: 10.1016/j.antiviral.2018.07.024
PMCID: PMC6146077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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