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Article

Evolution of resistant M414T mutants among hepatitis C virus replicon cells treated with polymerase inhibitor A-782759.

Antimicrobial agents and chemotherapy - 1 Jun 2007

Lu Liangjun, Mo Hongmei, Pilot-Matias Tami J, Molla Akhteruzzaman

Abstract excerpt

Treatment of hepatitis C virus (HCV) replicon cells with any single specific anti-HCV inhibitor in vitro leads to a rapid selection of resistant mutants. However, the source and the kinetic evolution of these resistant mutants during treatment are poorly understood. In this study we developed allele-specific real-time PCR assays for quantitative detection of the M414T mutant that was selected by a number of...

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Identifiers

PMID: 17371824
DOI: 10.1128/AAC.01004-06
PMCID: PMC1891376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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