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Chemical Synthesis Enables Biochemical and Antibacterial Evaluation of Streptolydigin Antibiotics

29 Jun 2011

Abstract excerpt

Inhibition of bacterial transcription represents an effective and clinically validated anti-infective chemotherapeutic strategy. We describe the evolution of our approach to the streptolydigin class of antibiotics that target bacterial RNA polymerases (RNAPs). This effort resulted in the synthesis and biological evaluation of streptolydigin, streptolydiginone, streptolic acid, and a series of new...

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PMID: 21714556
DOI: 10.1021/ja2041964

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