Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mycobacterium tuberculosis is resistant to streptolydigin.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2013

Speer Alexander, Rowland Jennifer L, Niederweis Michael

Abstract excerpt

Drug resistant strains of Mycobacterium tuberculosis (Mtb) undermine tuberculosis (TB) control. Streptolydigin is a broadly effective antibiotic which inhibits RNA polymerase, similarly to rifampicin, a key drug in current TB chemotherapeutic regimens. Due to a vastly improved chemical synthesis streptolydigin and derivatives are being promoted as putative TB drugs. The microplate Alamar Blue assay revealed that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoglycosides
Share to Antibiotics, Antitubercular
Share to Cell Membrane Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance

Share to Mycobacterium smegmatis

Share to Mycobacterium tuberculosis

Share to Porins

Source

Open in PubMed Open full text

Identifiers

PMID: 23591156
DOI: 10.1016/j.tube.2013.03.002
PMCID: PMC3681836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mycobacterium tuberculosis is resistant to streptolydigin.PMID 23591156Read ↗

Chemical Synthesis Enables Biochemical and Antibacterial Evaluation of Streptolydigin AntibioticsSemantic proximity Read ↗

Streptogramin antibiotics: mode of action and resistance.Semantic proximity Read ↗

Identification of the anti-mycobacterial functional properties of piperidinol derivatives.Semantic proximity Read ↗

Advancement of GyrB Inhibitors for Treatment of Infections Caused by Mycobacterium tuberculosis and Non-tuberculous MycobacteriaSemantic proximity Read ↗

Discovery and biosynthesis of persiathiacins: Unusual polyglycosylated thiopeptides active against multi-drug resistant tuberculosisSemantic proximity Read ↗

Secondary Metabolites from a New Antibiotic-Producing Endophytic Streptomyces Isolate Inhibited Pathogenic and Multidrug-Resistant Mycobacterium tuberculosis StrainsSemantic proximity Read ↗

Application of molecular genetic methods in macrolide, lincosamide and streptogramin resistance diagnostics and in detection of drug-resistant Mycobacterium tuberculosis.Semantic proximity Read ↗

The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosisSemantic proximity Read ↗

Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.Semantic proximity Read ↗

Saskemycin, a potent and selective antimycobacterial agent targeting a unique site on the ribosomeSemantic proximity Read ↗

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.Semantic proximity Read ↗

The emergence of resistance to the antiparasitic selamectin in Mycobacterium smegmatis is improbable and contingent on cell wall integrity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.