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Structure and Biosynthesis of the Antibiotic Bottromycin D

17 Sept 2012

Abstract excerpt

Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole...

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PMID: 22984777
DOI: 10.1021/ol3022758

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