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Article

The Nuclear Receptor TLX Is Required for Gliomagenesis within the Adult Neurogenic Niche

2 Oct 2012

Abstract excerpt

Neural stem cells (NSCs) continually generate functional neurons in the adult brain. Due to their ability to proliferate, deregulated NSCs or their progenitors have been proposed as the cells of origin for a number of primary central nervous system neoplasms, including infiltrating gliomas. The orphan nuclear receptor TLX is required for proliferation of adult NSCs, and its upregulation promotes brain tumor...

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PMID: 23028043
DOI: 10.1128/mcb.01122-12

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Related research

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The Nuclear Receptor TLX Is Required for Gliomagenesis within the Adult Neurogenic NichePMID 23028043Read ↗

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Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-MycSemantic proximity Read ↗

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A PML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNSSemantic proximity Read ↗

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