Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells.

Neuron - 19 Dec 2002

Doetsch Fiona, Petreanu Leopoldo, Caille Isabelle, Garcia-Verdugo Jose Manuel, Alvarez-Buylla Arturo

Abstract excerpt

Neural stem cells in the subventricular zone (SVZ) continue to generate new neurons in the adult brain. SVZ cells exposed to EGF in culture grow to form neurospheres that are multipotent and self-renewing. We show here that the majority of these EGF-responsive cells are not derived from relatively quiescent stem cells in vivo, but from the highly mitotic, Dlx2(+), transit-amplifying C cells. When exposed to EGF,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Cell Lineage
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Microscopy, Electron

Share to Spheroids, Cellular

Share to Stem Cells

Share to Up-Regulation

Source

Identifiers

PMID: 12495619
DOI: 10.1016/s0896-6273(02)01133-9

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells.PMID 12495619Read ↗

Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain.Semantic proximity Read ↗

Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cellsSemantic proximity Read ↗

Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS.Semantic proximity Read ↗

Neural Stem Cells, Neural Progenitors, and Neurotrophic FactorsSemantic proximity Read ↗

AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expression.Semantic proximity Read ↗

A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes.Semantic proximity Read ↗

A High Concentration of Epidermal Growth Factor Increases the Growth and Survival of Neurogenic Radial Glial Cells Within Human Neurosphere CulturesSemantic proximity Read ↗

Isolation of postnatal human neural stem cellsSemantic proximity Read ↗

Characterization of Adult Neural Stem Cells and Their Relation to Brain TumorsSemantic proximity Read ↗

In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brainSemantic proximity Read ↗

Establishment of an epidermal growth factor-dependent, multipotent neural precursor cell line.Semantic proximity Read ↗

Tumorigenic Potential of Olfactory Bulb-Derived Human Adult Neural Stem Cells Associates with Activation of TERT and NOTCH1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.