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Article

Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone

3 Feb 2022

Abstract excerpt

Neural stem cells (NSCs) in the adult brain are a source of neural cells for brain injury repair. We investigated whether their capacity to generate new neurons and glia is determined by thyroid hormone (TH) during development because serum levels peak during postnatal reorganization of the main NSC niche, the subventricular zone (SVZ). Re-analysis of mouse transcriptome data revealed increased expression of TH...

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PMID: 35120623
DOI: 10.1016/j.stemcr.2022.01.002

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