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Article

Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1.

Genes & development - 15 May 2006

Zhang Chun-Li, Zou Yuhua, Yu Ruth T, Gage Fred H, Evans Ronald M

Abstract excerpt

During mammalian embryogenesis, precise coordination of progenitor cell proliferation and differentiation is essential for proper organ size and function. The involvement of TLX (NR2E1), an orphan nuclear receptor, has been implicated in ocular development, as Tlx-/- mice exhibit visual impairment. Using genetic and biochemical approaches, we show that TLX modulates retinal progenitor cell proliferation and cell...

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Identifiers

PMID: 16702404
DOI: 10.1101/gad.1413606
PMCID: PMC1472905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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