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Article

Alteration in molecular properties during establishment and passaging of endometrial carcinoma patient-derived xenografts.

Scientific reports - 25 May 2023

Imai Toshio, Yoshida Hiroshi, Machida Yukino, Kuramochi Mizuki, Ichikawa Hitoshi, Kubo Takashi, Takahashi Mami, Kato Tomoyasu

Abstract excerpt

Patient-derived xenograft (PDX) tumor models are known to maintain the genomic and phenotypic profiles, including the histopathological structures, of the parental tumors. On the other hand, unique enrichment of single-nucleotide variants or copy number aberrations has been reported in several types of tumors. However, an understanding of endometrial carcinoma PDXs is limited. The purpose of the present study was...

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Identifiers

PMID: 37231035
DOI: 10.1038/s41598-023-35703-6
PMCID: PMC10212914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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