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Article

A new antigenic site of poliovirus recognized by an intertypic cross-neutralizing monoclonal antibody.

Virology - 1 Oct 1990

Uhlig J, Wiegers K, Dernick R

Abstract excerpt

A monoclonal antibody (mAb 7J6) neutralizing poliovirus type 2 (PV2) and poliovirus type 1 (PV1) was obtained after immunization of BALB/c mice with infectious PV2, strain MEF-1. Preincubation of mAb 7J6 with PV1 inhibited its binding to PV2 and vice versa. Neutralization-resistant variants of PV2 and PV1 were selected. Nucleotide sequencing of the RNAs of some variants revealed mutations in the loop of amino...

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Source

Identifiers

PMID: 2171198
DOI: 10.1016/0042-6822(90)90363-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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