A new antigenic site of poliovirus recognized by an intertypic cross-neutralizing monoclonal antibody.

doi:10.1016/0042-6822(90)90363-v

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Article

A new antigenic site of poliovirus recognized by an intertypic cross-neutralizing monoclonal antibody.

Virology - 1 Oct 1990

Uhlig J, Wiegers K, Dernick R

Abstract excerpt

A monoclonal antibody (mAb 7J6) neutralizing poliovirus type 2 (PV2) and poliovirus type 1 (PV1) was obtained after immunization of BALB/c mice with infectious PV2, strain MEF-1. Preincubation of mAb 7J6 with PV1 inhibited its binding to PV2 and vice versa. Neutralization-resistant variants of PV...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antigenic Variation
Binding Sites
Binding, Competitive
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation
Neutralization Tests
Poliovirus

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