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Article

Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins.

PLoS pathogens - 1 Feb 2018

Mousa Jarrod J, Binshtein Elad, Human Stacey, Fong Rachel H, Alvarado Gabriela, Doranz Benjamin J, Moore Martin L, Ohi Melanie D, Crowe James E

Abstract excerpt

Respiratory syncytial virus (RSV) is a major human pathogen that infects the majority of children by two years of age. The RSV fusion (F) protein is a primary target of human antibodies, and it has several antigenic regions capable of inducing neutralizing antibodies. Antigenic site IV is preserved in both the pre-fusion and post-fusion conformations of RSV F. Antibodies to antigenic site IV have been described...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29470533
DOI: 10.1371/journal.ppat.1006837
PMCID: PMC5823459

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