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A detailed mutagenesis study of flavivirus cross-reactive epitopes using West Nile virus-like particles

20 Mar 2007

Abstract excerpt

Human flavivirus infections elicit virus species-specific and cross-reactive immune responses. The flavivirus envelope (E) glycoprotein is the primary antigen inducing protective immunity; however, the presence of cross-reactive antibodies in human sera creates problems for serodiagnosis. Using a West Nile virus-like particle system, we performed mutagenesis across all three E protein functional domains to...

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PMID: 17374760
DOI: 10.1099/vir.0.82640-0

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