Article
Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice.
Genesis (New York, N.Y. : 2000) - 1 Feb 2001
Chandler J, Hohenstein P, Swing D A, Tessarollo L, Sharan S K
Abstract excerpt
Half of all familial breast cancers are due to mutation in the BRCA1 gene. However, despite its importance, attempts to model BRCA1-induced disease in the mouse have been disappointing. Heterozygous Brca1 knockout mice do not develop mammary tumors and homozygous knockout mice die during embryogenesis from ill-defined causes. Sequence analysis has shown that the coding region, genomic organization, and regulatory...
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