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Article

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.

The Journal of clinical investigation - 1 Oct 2009

Chang Suhwan, Biswas Kajal, Martin Betty K, Stauffer Stacey, Sharan Shyam K

Abstract excerpt

To date, inheritance of a mutant BRCA1 or BRCA2 gene is the best-established indicator of an increased risk of developing breast cancer. Sequence analysis of these genes is being used to identify BRCA1/2 mutation carriers, though these efforts are hampered by the high frequency of variants of unk...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19770520
DOI: 10.1172/JCI39836
PMCID: PMC2752086

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19770520-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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