Article
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations.
The Journal of clinical investigation - 1 Oct 2009
Chang Suhwan, Biswas Kajal, Martin Betty K, Stauffer Stacey, Sharan Shyam K
Abstract excerpt
To date, inheritance of a mutant BRCA1 or BRCA2 gene is the best-established indicator of an increased risk of developing breast cancer. Sequence analysis of these genes is being used to identify BRCA1/2 mutation carriers, though these efforts are hampered by the high frequency of variants of unknown clinical significance (VUSs). Functional evaluation of such variants has been restricted due to lack of a...
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