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Article

Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk.

BMC cancer - 27 Jun 2011

Ricks-Santi Luisel J, Sucheston Lara E, Yang Yang, Freudenheim Jo L, Isaacs Claudine J, Schwartz Marc D, Dumitrescu Ramona G, Marian Catalin, Nie Jing, Vito Dominica, Edge Stephen B, Shields Peter G

Abstract excerpt

BACKGROUND: Inter-individual variation in DNA repair capacity is thought to modulate breast cancer risk. The phenotypic mutagen sensitivity assay (MSA) measures DNA strand breaks in lymphocytes; women with familial and sporadic breast cancers have a higher mean number of breaks per cell (MBPC) than women without breast cancer. Here, we explore the relationships between the MSA and the Rad51 gene, which encodes a...

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Identifiers

PMID: 21708019
DOI: 10.1186/1471-2407-11-278
PMCID: PMC3146938

Genes

BRCA1
BRCA2

Variants

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