Article
Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.
Breast cancer research and treatment - 1 May 2010
Loizidou Maria A, Cariolou Marios A, Neuhausen Susan L, Newbold Robert F, Bashiardes Evy, Marcou Yiola, Michael Thalia, Daniel Maria, Kakouri Eleni, Papadopoulos Panayiotis, Malas Simon, Hadjisavvas Andreas, Kyriacou Kyriacos
Abstract excerpt
Inability to correctly repair DNA damage is known to play a role in the development of breast cancer. Single nucleotide polymorphisms (SNPs) of DNA repair genes have been identified, which modify the DNA repair capacity, which in turn may affect the risk of developing breast cancer. To assess whether alterations in DNA repair genes contribute to breast cancer, we genotyped 62 SNPs in 29 genes in 1,109 Cypriot...
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