Article
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2001
Wang W W, Spurdle A B, Kolachana P, Bove B, Modan B, Ebbers S M, Suthers G, Tucker M A, Kaufman D J, Doody M M, Tarone R E, Daly M, Levavi H, Pierce H, Chetrit A, Yechezkel G H, Chenevix-Trench G, Offit K, Godwin A K, Struewing J P
Abstract excerpt
RAD51 colocalizes with both BRCA1 and BRCA2, and genetic variants in RAD51 would be candidate BRCA1/2 modifiers. We searched for RAD51 polymorphisms by sequencing 20 individuals. We compared the polymorphism allele frequencies between female BRCA1/2 mutation carriers with and without breast or ov...
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