Article
The RAD51D E233G variant and breast cancer risk: population-based and clinic-based family studies of Australian women.
Breast cancer research and treatment - 1 Nov 2008
Dowty James G, Lose Felicity, Jenkins Mark A, Chang Jiun-Horng, Chen XiaoQing, Beesley Jonathan, Dite Gillian S, Southey Melissa C, Byrnes Graham B, Tesoriero Andrea, Giles Graham G, Hopper John L, Spurdle Amanda B
Abstract excerpt
RAD51D is a homolog of the RAD51 protein, which is known to be an important component of the DNA repair pathway. A rare missense variant in the RAD51D gene, E233G (c.A>G), has been reported to be more prevalent in breast cancer cases from specific multiple-case breast cancer families, with an odds ratio of 2.6 (95% confidence interval (CI): 1.12-6.03). We assessed whether this variant was associated with breast...
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