Article
Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer.
Scientific reports - 24 Jan 2018
Gao Bo, Lu Yi, Nieuweboer Annemieke J M, Xu Hongmei, Beesley Jonathan, Boere Ingrid, de Graan Anne-Joy M, de Bruijn Peter, Gurney Howard, J Kennedy Catherine, Chiew Yoke-Eng, Johnatty Sharon E, Beale Philip, Harrison Michelle, Luccarini Craig, Conroy Don, Mathijssen Ron H J, R Harnett Paul, Balleine Rosemary L, Chenevix-Trench Georgia, Macgregor Stuart, de Fazio Anna
Abstract excerpt
Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity. Genome-wide approaches are unbiased, compared with candidate gene studies, but usually require large cohorts. As most chemotherapy is given cyclically multiple blood sampling is required to adequately define drug disposition, limiting patient recruitment. We found...
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