Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative analyses of genetic variation, epigenetic regulation, and the transcriptome to elucidate the biology of platinum sensitivity.

BMC genomics - 16 Apr 2014

LaCroix Bonnie, Gamazon Eric R, Lenkala Divya, Im Hae Kyung, Geeleher Paul, Ziliak Dana, Cox Nancy J, Huang Rong Stephanie

Abstract excerpt

BACKGROUND: Using genome-wide genetic, gene expression, and microRNA expression (miRNA) data, we developed an integrative approach to investigate the genetic and epigenetic basis of chemotherapeutic sensitivity. RESULTS: Through a sequential multi-stage framework, we identified genes and miRNAs w...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to ATP-Binding Cassette Transporters
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to MicroRNAs

Share to Platinum

Share to Reproducibility of Results

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 24739237
DOI: 10.1186/1471-2164-15-292
PMCID: PMC3996490

Genes

ABCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24739237-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative analyses of genetic variation, epigenetic regulation, and the transcriptome to elucidate the biology of platinum sensitivity.PMID 24739237Read ↗

Genetic variation that predicts platinum sensitivity reveals the role of miR-193b* in chemotherapeutic susceptibility.Semantic proximity Read ↗

Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.Semantic proximity Read ↗

Pharmacogenomics of platinum-based chemotherapy in NSCLCSemantic proximity Read ↗

Genome-Wide Mapping of Cisplatin Damaged Gene LociSemantic proximity Read ↗

Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach.Semantic proximity Read ↗

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-WideSemantic proximity Read ↗

Genetically regulated expression underlies cellular sensitivity to chemotherapy in diverse populationsSemantic proximity Read ↗

Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patientsSemantic proximity Read ↗

Systematic identification of genomic markers of drug sensitivity in cancer cellsSemantic proximity Read ↗

Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance DevelopmentSemantic proximity Read ↗

Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.Semantic proximity Read ↗

Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.