Article
Integrative analyses of genetic variation, epigenetic regulation, and the transcriptome to elucidate the biology of platinum sensitivity.
BMC genomics - 16 Apr 2014
LaCroix Bonnie, Gamazon Eric R, Lenkala Divya, Im Hae Kyung, Geeleher Paul, Ziliak Dana, Cox Nancy J, Huang Rong Stephanie
Abstract excerpt
BACKGROUND: Using genome-wide genetic, gene expression, and microRNA expression (miRNA) data, we developed an integrative approach to investigate the genetic and epigenetic basis of chemotherapeutic sensitivity. RESULTS: Through a sequential multi-stage framework, we identified genes and miRNAs whose expression correlated with platinum sensitivity, mapped these to genomic loci as quantitative trait loci (QTLs),...
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