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Article

Stock culture heterogeneity rather than new mutational variation complicates short-term cell physiology studies of Escherichia coli K-12 MG1655 in continuous culture.

Microbiology (Reading, England) - 1 Sept 2011

Nahku Ranno, Peebo Karl, Valgepea Kaspar, Barrick Jeffrey E, Adamberg Kaarel, Vilu Raivo

Abstract excerpt

Nutrient-limited continuous cultures in chemostats have been used to study microbial cell physiology for over 60 years. Genome instability and genetic heterogeneity are possible uncontrolled factors in continuous cultivation experiments. We investigated these issues by using high-throughput (HT) DNA sequencing to characterize samples from different phases of a glucose-limited accelerostat (A-stat) experiment with...

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Identifiers

PMID: 21700661
DOI: 10.1099/mic.0.050658-0
PMCID: PMC3352173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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