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Unexpected Discovery of Hypermutator Phenotype Sounds the Alarm for Quality Control Strains.

Genome biology and evolution - 3 Aug 2021

Wu Kun, Cheng Zhou-Hua, Williams Emily, Turner Nathan T, Ran Dapeng, Li Haichao, Zhou Xia, Guo Huilin, Sung Way, Liu Dong-Feng, Lynch Michael, Long Hongan

Abstract excerpt

Microbial strains with high genomic stability are particularly sought after for testing the quality of commercial microbiological products, such as biological media and antibiotics. Yet, using mutation-accumulation experiments and de novo assembled complete genomes based on Nanopore long-read sequencing, we find that the widely used quality-control strain Shewanella putrefaciens ATCC-8071, also a facultative...

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PMID: 34180992
DOI: 10.1093/gbe/evab148
PMCID: PMC8350357

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