Article
A poxvirus vaccine is safe, induces T-cell responses, and decreases viral load in patients with chronic hepatitis C.
Gastroenterology - 1 Sept 2011
Habersetzer François, Honnet Géraldine, Bain Christine, Maynard-Muet Marianne, Leroy Vincent, Zarski Jean-Pierre, Feray Cyrille, Baumert Thomas F, Bronowicki Jean-Pierre, Doffoël Michel, Trépo Christian, Agathon Delphine, Toh Myew-Ling, Baudin Martine, Bonnefoy Jean-Yves, Limacher Jean-Marc, Inchauspé Geneviève
Abstract excerpt
BACKGROUND & AIMS: Therapy for chronic hepatitis C (CHC) has limited efficacy, adverse effects, and high costs. Cohort and vaccine-based preclinical studies have indicated the importance of T-cell-based immunity in controlling viral infection. TG4040 is a recombinant poxvirus vaccine that express...
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