Article
Recognition of Core- and Polymerase-derived immunogenic peptides included in novel therapeutic vaccine by T cells from Chinese chronic hepatitis B patients.
Journal of viral hepatitis - 1 Nov 2017
Huang D, Sansas B, Jiang J H, Gong Q M, Jin G D, Calais V, Yu D M, Zhu M Y, Wei D, Zhang D H, Inchauspé G, Zhang X X, Zhu R
Abstract excerpt
Chronic hepatitis B (CHB) is one of the major public health challenges in the world. Due to a strong interplay between specific T-cell immunity and elimination of hepatitis B virus (HBV), efforts to develop novel immunotherapeutics are gaining attention. TG1050, a novel immunotherapy, has shown efficacy in an animal study. To support the clinical development of TG1050 in China, specific immunity to the fusion...
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