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Article

Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin.

The Journal of physiology - 1 Mar 2003

Chin Eva R, Grange Robert W, Viau Francois, Simard Alain R, Humphries Caroline, Shelton John, Bassel-Duby Rhonda, Williams R Sanders, Michel Robin N

Abstract excerpt

The purpose of this study was to determine whether induced expression of the Ca2+ buffering protein parvalbumin (PV) in slow-twitch fibres would lead to alterations in physiological, biochemical and molecular properties reflective of a fast fibre phenotype. Transgenic (TG) mice were generated that overexpressed PV in slow (type I) muscle fibres. In soleus muscle (SOL; 58 % type I fibres) total PV expression was...

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Identifiers

PMID: 12562945
DOI: 10.1113/jphysiol.2002.024760
PMCID: PMC2342652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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