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Article

Sarcolipin deletion in mdx mice impairs calcineurin signalling and worsens dystrophic pathology

17 Aug 2018

Abstract excerpt

Duchenne muscular dystrophy (DMD) is the most severe form of muscular dystrophy affecting 1 in 3500 live male births. Although there is no cure for DMD, therapeutic strategies aimed at enhancing calcineurin signalling and promoting the slow fibre phenotype have shown promise in mdx mice, which is the classical mouse model for DMD. Sarcolipin (SLN) is a small protein that regulates the sarco(endo)plasmic reticulum...

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PMID: 30137316
DOI: 10.1093/hmg/ddy302

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