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Article

Wip1 over-expression correlated with TP53/p14(ARF) pathway disruption in human astrocytomas.

Journal of surgical oncology - 1 Nov 2011

Wang Peng, Rao Jing, Yang Haifeng, Zhao Hongyang, Yang Lin

Abstract excerpt

PURPOSE: Wip1 over-expression inhibits p53 function and reduces selection for TP53 mutations during cancer progression. To clarify the correlation of Wip1 with TP53/p14(ARF) pathway disruption in astyrocytomas, the expression of Wip1 and TP53/p14(ARF) pathway alterations have been investigated. METHODS: Tumor samples of 52 patients of astrocytomas were examined for TP53 mutations, p14(ARF) expression, and Wip1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21695702
DOI: 10.1002/jso.22004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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