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Article

p53 Gene repair with zinc finger nucleases optimised by yeast 1-hybrid and validated by Solexa sequencing.

PloS one - 1 Jan 2011

Herrmann Frank, Garriga-Canut Mireia, Baumstark Rebecca, Fajardo-Sanchez Emmanuel, Cotterell James, Minoche André, Himmelbauer Heinz, Isalan Mark

Abstract excerpt

The tumor suppressor gene p53 is mutated or deleted in over 50% of human tumors. As functional p53 plays a pivotal role in protecting against cancer development, several strategies for restoring wild-type (wt) p53 function have been investigated. In this study, we applied an approach using gene repair with zinc finger nucleases (ZFNs). We adapted a commercially-available yeast one-hybrid (Y1H) selection kit to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21695267
DOI: 10.1371/journal.pone.0020913
PMCID: PMC3111460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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