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Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice

1 Jun 2006

Abstract excerpt

The millions of common DNA variations that occur in the human population, or among inbred strains of mice and rats, perturb the expression (transcript levels) of a large fraction of the genes expressed in a particular tissue. The hundreds or thousands of common cis-acting variations that occur in the population may in turn affect the expression of thousands of other genes by affecting transcription factors,...

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PMID: 16783628
DOI: 10.1007/s00335-005-0175-z

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