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Article

Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.

Nature genetics - 1 Feb 2006

Oh Seung Wook, Mukhopadhyay Arnab, Dixit Bharat L, Raha Tamal, Green Michael R, Tissenbaum Heidi A

Abstract excerpt

DAF-16, a forkhead transcription factor, is a key regulator of longevity, metabolism and dauer diapause in Caenorhabditis elegans. The precise mechanism by which DAF-16 regulates multiple functions, however, is poorly understood. Here, we used chromatin immunoprecipitation (ChIP) to identify direct targets of DAF-16. We cloned 103 target sequences containing consensus DAF-16 binding sites and selected 33 targets...

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PMID: 16380712
DOI: 10.1038/ng1723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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