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Identification of the SARS-CoV-2 genome packaging signal in the nsp12-coding region.

Nature communications - 10 Jul 2026

Park Youngran, Lim Jongmin, Cho Hyeonggon, Son Ahyeon, Jeong Minseok, Lee Young-Suk, Kim V Narry

Abstract excerpt

Selective genome packaging is a critical step for RNA viruses, which must distinguish genomic RNA from other abundant transcripts. For SARS-CoV-2, the cis-acting packaging signal is thought to be recognized by the nucleocapsid (N) protein, but its identity and mechanistic basis for selective recognition remain undefined. Here we identify the packaging signal within the nsp12 polymerase-coding region. CLIP-seq...

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Coronavirus Nucleocapsid Proteins
COVID-19
Frameshifting, Ribosomal
Genome, Viral
Mutation

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PMID: 42425967
DOI: 10.1038/s41467-026-75008-6
PMCID: PMC13482826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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