Article
Identification of an amino acid substitution in human alpha 1 Na,K-ATPase which confers differentially reduced affinity for two related cardiac glycosides.
The Journal of biological chemistry - 30 Sept 1994
Askew G R, Lingrel J B
Abstract excerpt
The ouabain-resistant cell line H1C1 displays a 30-fold differential of reduced sensitivity to the structurally related cardiac glycosides digoxin and digitoxin (Baker, R. M. (1976) in Biogenesis and Turnover of Membrane Macromolecules (Cook, J.S., ed) pp. 93-103, Raven Press, New York). Since these ligand congeners differ only by the presence of a hydroxyl group at C-12 of digoxin we predicted that the H1C1...
Topics
- Amino Acid Sequence
- Amino Acids
- Base Sequence
- Cardiac Glycosides
- DNA, Complementary
- Digitoxin
- Digoxin
- HeLa Cells
- Humans
- Molecular Sequence Data
- Phenotype