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Article

Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants.

Mutation research - 1 Jun 1994

Cantoni O, Hussain S, Guidarelli A, Cattabeni F

Abstract excerpt

Hydrogen peroxide-resistant Chinese hamster ovary (CHO) cells displayed cross-resistance to CdCl2, HgCl2 and NaAsO2 but not to Na2Cr2O7, ZnCl2, NiCl2 and CuSO4. Resistance to hydrogen peroxide and to the metals was partially retained by these cells for many generations despite growth in drug-free medium. The loss of resistance was a slow process, and was different for the various metal compounds. Cell variants...

Topics

Animals
CHO Cells
Cell Division
Cricetinae
Drug Resistance
Genetic Variation
Hydrogen Peroxide
Metallothionein
Metals
Sulfhydryl Compounds

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7515463
DOI: 10.1016/0165-7992(94)90059-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7515463-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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