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Article

Modulation of pump function by mutations in the first transmembrane region of Na(+)-K(+)-ATPase alpha 1-subunit.

The American journal of physiology - 1 Feb 1996

Yamamoto S, Askew G R, Heiny J, Masaki H, Yatani A

Abstract excerpt

The Cys in the first transmembrane region of the Na(+)-K(+)-adenosinetriphosphatase (ATPase) alpha 1-subunit has been shown to be a critical determinant of cardiac glycoside binding. To study the role of this Cys on ion transport activity, we measured pump currents in HeLa cells expressing wild-type or mutant alpha 1-subunit cDNAs. The endogenous ouabainsensitive Na(+)-K(+)-ATPase was selectively inhibited by...

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PMID: 8779907
DOI: 10.1152/ajpcell.1996.270.2.C457

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