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Article

Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice.

The Journal of biological chemistry - 5 Sept 2003

Dawson Paul A, Haywood Jamie, Craddock Ann L, Wilson Martha, Tietjen Mary, Kluckman Kimberly, Maeda Nobuyo, Parks John S

Abstract excerpt

The ileal apical sodium bile acid cotransporter participates in the enterohepatic circulation of bile acids. In patients with primary bile acid malabsorption, mutations in the ileal bile acid transporter gene (Slc10a2) lead to congenital diarrhea, steatorrhea, and reduced plasma cholesterol levels. To elucidate the quantitative role of Slc10a2 in intestinal bile acid absorption, the Slc10a2 gene was disrupted by...

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PMID: 12819193
DOI: 10.1074/jbc.M306370200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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