Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.

Biochemical pharmacology - 14 Aug 2006

Maher J M, Slitt A L, Callaghan T N, Cheng X, Cheung C, Gonzalez F J, Klaassen C D

Abstract excerpt

The transcription factor hepatocyte nuclear factor 1alpha (HNF1alpha) is involved in regulation of glucose metabolism and transport, and in the expression of several drug and bile acid metabolizing enzymes. Targeted disruption of the HNF1alpha gene results in decreased Cyp1a2, and Cyp2e1 expressi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Duodenum

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Kidney

Share to Membrane Transport Proteins

Share to Multidrug Resistance-Associated Proteins

Share to Organic Anion Transporters, Sodium-Independent

Source

Identifiers

PMID: 16806085
DOI: 10.1016/j.bcp.2006.03.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16806085-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.PMID 16806085Read ↗

HNF4α in Hepatocyte Health and DiseaseSemantic proximity Read ↗

Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.Semantic proximity Read ↗

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.Semantic proximity Read ↗

Transcriptional profiling of the zebrafish proximal tubuleSemantic proximity Read ↗

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseasesSemantic proximity Read ↗

Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function.Semantic proximity Read ↗

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesisSemantic proximity Read ↗

Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis.Semantic proximity Read ↗

Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulationSemantic proximity Read ↗

Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transportersSemantic proximity Read ↗

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liverSemantic proximity Read ↗

Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.