Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients.

BMC medical genetics - 20 Jun 2011

Qiao Boling, Scott Gina B, Elliott Faye, Vaslin Laurence, Bentley Johanne, Hall Janet, Bishop D Timothy, Knowles Margaret A, Kiltie Anne E

Abstract excerpt

BACKGROUND: XPC is involved in the nucleotide excision repair of DNA damaged by carcinogens known to cause bladder cancer. Individuals homozygous for the variant allele of XPC c.1496C > T (p.Ala499Val) were shown in a large pooled analysis to have an increased bladder cancer risk, and we found two 3'UTR variants, *611T > A and c.*618A > G, to be in strong linkage disequilibrium with c.1496T. Here we determined if...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homozygote

Share to Protein Biosynthesis

Share to RNA, Messenger

Share to RNA Stability

Share to Transcription, Genetic

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 21689419
DOI: 10.1186/1471-2350-12-84
PMCID: PMC3142493

Genes

XPC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients.PMID 21689419Read ↗

In vitro functional effects of XPC gene rare variants from bladder cancer patients.Semantic proximity Read ↗

Comprehensive analysis of 22 XPC polymorphisms and bladder cancer risk.Semantic proximity Read ↗

EGFR 3'UTR 774T>C polymorphism contributes to bladder cancer risk.Semantic proximity Read ↗

Polymorphisms in the XPC gene affect urinary bladder cancer risk: a case-control study, meta-analyses and trial sequential analyses.Semantic proximity Read ↗

Reduced XPC DNA repair gene mRNA levels in clinically normal parents of xeroderma pigmentosum patients.Semantic proximity Read ↗

A 3'UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1.Semantic proximity Read ↗

Single nucleotide polymorphisms of the DNA repair gene XPD/ERCC2 alter mRNA expression.Semantic proximity Read ↗

Two essential splice lariat branchpoint sequences in one intron in a xeroderma pigmentosum DNA repair gene: mutations result in reduced XPC mRNA levels that correlate with cancer risk.Semantic proximity Read ↗

In silico whole-genome screening for cancer-related single-nucleotide polymorphisms located in human mRNA untranslated regions.Semantic proximity Read ↗

A functional variant in TP63 at 3q28 associated with bladder cancer risk by creating an miR-140-5p binding site.Semantic proximity Read ↗

The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function.Semantic proximity Read ↗

XPC branch-point sequence mutations disrupt U2 snRNP binding, resulting in abnormal pre-mRNA splicing in xeroderma pigmentosum patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.