Article
In vitro functional effects of XPC gene rare variants from bladder cancer patients.
Carcinogenesis - 1 Apr 2011
Qiao Boling, Ansari Abdul-Haq, Scott Gina B, Sak Sei C, Chambers Philip A, Elliott Faye, Teo Mark T W, Bentley Johanne, Churchman Michael, Hall Janet, Taylor Claire F, Bishop Timothy D, Knowles Margaret A, Kiltie Anne E
Abstract excerpt
The XPC gene is involved in repair of bulky DNA adducts formed by carcinogenic metabolites and oxidative DNA damage, both known bladder cancer risk factors. Single nucleotide polymorphisms (SNPs) in XPC have been associated with increased bladder cancer risk. Recently, rarer genetic variants have been identified but it is difficult to ascertain which are of functional importance. During a mutation screen of XPC...
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