Article
A functional variant in TP63 at 3q28 associated with bladder cancer risk by creating an miR-140-5p binding site.
International journal of cancer - 1 Jul 2016
Wang Meilin, Du Mulong, Ma Lan, Chu Haiyan, Lv Qiang, Ye Dingwei, Guo Jianming, Gu Chengyuan, Xia Guowei, Zhu Yao, Ding Qiang, Yuan Lin, Fu Guangbo, Tong Na, Qin Chao, Yin Changjun, Xu Jianfeng, Zhang Zhengdong
Abstract excerpt
The first genome-wide association study (GWAS) for bladder cancer has identified a susceptibility locus at 3q28 in the European ancestry. However, the causal variant at 3q28 remains unknown. We conducted a three-stage fine mapping study to identify potential causal variants in the region. A total of 41 single nucleotide polymorphisms (SNPs) across 120 kb at 3q28 were tested for association with bladder cancer...
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